Lose Weight On Risperidone
Weight gain can be a difficult side effect for people taking antipsychotic medications. Not all drugs are equally likely to cause weight gain, and this post looks at the findings from a study published in 2020 in The Lancet Psychiatry that compared the potential for weight gain with different antipsychotics.
To start, let’s talk about why antipsychotics can cause weight gain. There are multiple different neurotransmitter pathways that can play a role in weight and metabolism. These pathways involve different types of neurotransmitters and specific receptor types that may be agonized (boosting their activity doing whatever it is they normally do) or antagonized (blocking/reducing their activity).
Antipsychotics across the board are characterized by their antagonist activity at D2 dopamine receptors, and atypical (newer) antipsychotics also antagonize 5HT2a serotonin receptors, but besides that, all of the antipsychotics also interact with a variety of other receptor types, and the exact mix varies from one drug to another.
Pdf] Weight Gain In Asian Patients On Second Generation Antipsychotics.
The likelihood of a medication causing weight gain depends on how involved the medication gets in a few particular pathways, which include:
Antipsychotics can also increase cholesterol and triglycerides and increase insulin resistance and diabetes risk. Together, these effects, along with hypertension, are known as metabolic syndrome, and people taking atypically antipsychotics should be assessed for this a couple of times per year. Atypicals are more likely than typicals to contribute to metabolic syndrome.
I’ve omitted a few of the less commonly used drugs that were mentioned, but the drugs that were associated with weight gain, listed from the most weight gain to the least, were:
Weight Gain: Olanzapine Compared With Risperidone
Clozapine, olanzapine, and quetiapine were all linked to increases in cholesterol and triglycerides. Lurasidone, ziprasidone, and cariprazine were less likely than placebo to be associated with an increase in cholesterol.
All of these findings are averages, and for a given individual, a lower-risk drug may end up causing more problems than a higher-risk drug, or a drug that’s generally associated with weight loss may cause weight gain. All of our bodies are a little different, so there’s variability in how we respond.
The key issue is what works in treating the illness. Clozapine is hands down the worse culprit for metabolic syndrome, but at the same time, it’s also hands down the most effective antipsychotic there is, especially for people who don’t respond well to other drugs. Plus it’s the only antipsychotic that can improve tardive dyskinesia (an antipsychotic-induced involuntary movement disorder).
Top Risperidone Alternatives And How To Switch Your Rx
Where medication change isn’t an option, metformin (a diabetes medication) or topiramate (an anticonvulsant) are sometimes used to offset some of the weight gain. Adding on extra medication to manage side effects isn’t ideal, so they’re not used routinely, but they’re options, especially for people who are on clozapine.
I’ve gained a lot of weight on quetiapine, but my cholesterol, triglycerides, and blood glucose have been fine thus far. I’ve also tried olanzapine and aripiprazole in the past, and I suppose I could fuss around trying to find something else that would work but not have metabolic effects, but I just can’t be bothered. I can live with my weight. I have no desire to screw up my med regimen and make things worse.
Pillinger, T., McCutcheon, R. A., Vano, L., Mizuno, Y., Arumuham, A., Hindley, G., … & Howes, O. D. (2020). Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: A systematic review and network meta-analysis.
Risperidone Side Effects And How To Avoid Them
Want to know more about psych meds and how they work? Psych Meds Made Simple is everything you didn’t realize you wanted to know about medications.As a personal trainer, I get to know many of my clients’ on a deeper level during our personal training sessions in my Carlsbad gym. Several of them have shared their struggles with weight gain while taking psychiatric medications like Abilify, lithium, risperidone, and even common antidepressants like Prozac.
These psychiatric medications are prescribed to stabilize mood, reduce irritability, and manage other symptoms associated with conditions like bipolar and depression. They can literally save lives, but they can also cause significant weight gain--one of my personal training clients gained 50 pounds in six months on Abilify!
I’m not sharing this to scare you into refusing a prescription you may need in order to live a healthy, fulfilling life. In fact, I’m here to say that the weight gain on medications like Abilify and lithium is not inevitable. You can prevent it if you’re willing to do the work to live a healthy lifestyle!
Risk Of Weight Gain For Specific Antipsychotic Drugs: A Meta Analysis
It’s unclear why some psychiatric medications cause weight gain. Lithium, for example, causes weight gain in about 25% of the people who take it. However, the exact mechanism is unknown. Lithium does cause thirst, so it’s possible that people are quenching that thirst with high-calorie drinks like soda. It’s also possible that lithium affects the thyroid.
Things are more clear for mood stabilizers/atypical antipsychotics like Abilify and risperidone. These medications can stimulate appetite, which leads to eating more calories than you need to maintain your normal weight. Even an excess of 100 calories per day--the equivalent of less than half a bag of M&Ms--can lead to a 10 pound weight gain in just under a year.
Many people who take them also have high blood levels of lipids and glucose, which can be a sign of metabolic syndrome. It’s unclear whether this is caused by overeating or by the medication itself. Either way, metabolic syndrome is not something you want in your life. It not only makes it harder to lose weight, but it also increases your risk of heart disease, stroke, and Type 2 diabetes.
Ocd Treatment: Is Ex/rp More Effective Than Risperidone?
The good news is that you can take the medications your doctor recommends and still maintain a normal weight. It just takes some work.
First of all, remember that everyone responds to medications differently. If one medication causes weight gain for you, another in the same category may be equally effective yet weight neutral. For example, Latuda (another mood stabilizer/atypical antipsychotic) is known to cause less weight gain than Abilify, and Abilify may cause less weight gain than risperidone.
If changing medications doesn’t help or isn’t an option, lifestyle changes can be a powerful tool for preventing weight gain on medications--this approach just takes more work on your part.
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Like I said, I’ve had several personal training clients at my gym in Carlsbad who have taken mood stabilizers like Abilify and successfully lost or maintained their weight. Here’s what worked for them:
If you’re not familiar with HIIT, it’s when you exercise for a short period of time (usually about 20 minutes) and alternate between low effort activity and high effort activity. One of my favorite HIIT exercises is doing sprints on a stationary bike in my Carlsbad personal training gym. Alternate between 30 seconds of easy pedaling with 20 seconds as fast as you can do. Do this for anywhere from 5 to 20 minutes for an intense exercise that burns a ton of calories and revs up your metabolism.
While HIIT burns lots of calories in a matter of minutes, endurance sports like running or swimming laps can be equally effective if you’re willing to put in the time. Some of my personal training clients prefer steady endurance activities over the bursts of energy required in HIIT. It’s up to you what you prefer, although I would recommend a fitness program that combines the two for maximum benefit.
Does Latuda Cause Weight Gain?
Even a small increase in calories can cause significant weight gain. It’s very hard not to eat more when your medication hijacks your appetite and makes you crave sugary, fatty foods. If you just go off how you feel, you will very likely eat more food than you need when taking medications like Abilify.
To counter this, I recommend tracking your calories in a fitness app like MyFitnessPal. This will make you more mindful of how many calories you’ve eaten and help you balance your intake with what you’re burning through exercise.
Yes, calorie counting is a pain when you do it day-after-day. But it’s such an effective way of seeing your trends in your diet and keeping your eating in check. It’s also helpful if you end up seeing a dietician or other nutritional specialist as they can see at a glance what you are eating.
Pdf) Metformin: An Effective Attenuator Of Risperidone Induced Insulin Resistance Hyperglycemia And Dyslipidemia In Rats
My recommended calorie and macronutrient goals vary by person. For me personally, I shoot for less than 22 grams of sugar per day (almost always in the form of fruit). I also try to keep my healthy fat intake at 25% of my calories.
If you’re actively losing weight, you want to prevent muscle loss, so it’s important to increase your protein intake as well. Specifically, aim for .7 to 1 gram of protein per pound of bodyweight per day. This may seem like a lot, but a higher level of protein will help you maintain muscle mass and also makes you feel more full in between meals.
I’ve personally gone back and forth on the Paleo diet over the years. Whole grains (which are not Paleo) are a great source of fiber and healthy carbohydrates, but I go through phases where it seems like my
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